Dr. Walter Brice House and Office is a historic plantation house and office located near Winnsboro, Fairfield County, South Carolina. It was built about 1840, and is a two-story, weatherboarded frame, L-shaped Greek Revival style dwelling. It features a two-tiered, pedimented front verandah supported by four wooden pillars. The Dr. Walter Brice Office is a 10-foot-by-12-foot weatherboarded frame building with a metal gable roof. Dr. Walter Brice (1804 - ca. 1871) was a prominent Fairfield County planter and physician before the American Civil War.