Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, like arachidonic acid, 20 carbon units in length. Eicosanoids function in diverse physiological and pathological systems including those: mounting or inhibiting inflammation, allergy, fever and other immune responses; influencing the abortion of pregnancy and normal childbirth; contributing to the perception of pain; regulating cell growth; controlling blood pressure; and modulating the regional flow of blood to tissues. In performing these tasks, eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to impact cells near to their cells of origin. However, they can a