Habsburg Spain refers to the history of Spain over the 16th and 17th centuries (1516–1700), when Spain was ruled by the major branch of the Habsburg dynasty (also associated with its role in the history of Central Europe). The Habsburg rulers (chiefly Charles V and Philip II) reached the zenith of their influence and power. They controlled territory that included the Americas, the East Indies, the Low Countries and territories now in France and Germany in Europe, the Portuguese Empire from 1580 to 1640, and various other territories such as small enclaves like Ceuta and Oran in North Africa. This period of Spanish history has also been referred to as the "Age of Expansion".