Holy Cross Church is a Roman Catholic church located at 329 West 42nd Street between Eighth and Ninth Avenues in the Hell's Kitchen neighborhood of Manhattan, New York City, near Times Square and across the street from the Port Authority Bus Terminal. Since 1900, Holy Cross Church has worked with politicians, police and community groups to combat poverty, crime and drugs in the neighborhood. The parish is especially associated with the popular ministry of the Reverend Francis P. Duffy.