Hotel Oregon, also known as Oakman Drugs, Oakman Glass, and Spartan Hotel, is a historic hotel building located at Spartanburg, Spartanburg County, South Carolina. It was built in 1909, and is a three-story, brick building with two first floor storefronts. It features horizontal granite belt courses, decorative brick panels, brick cornices, and a stepped front parapet. It was listed on the National Register of Historic Places in 2001.