The Italian Wars, often referred to as the Great Italian Wars or the Great Wars of Italy and sometimes as the Habsburg–Valois Wars or the Renaissance Wars, were a series of conflicts from 1494 to 1559 that involved, at various times, most of the city-states of Italy, the Papal States, most of the major states of Western Europe (France, Spain, the Holy Roman Empire, England, and Scotland) as well as the Ottoman Empire. Originally arising from dynastic disputes over the Duchy of Milan and the Kingdom of Naples, the wars rapidly became a general struggle for power and territory among their various participants, and were marked with an increasing number of alliances, counter-alliances, and betrayals.