Knox United Church is a designated municipal heritage building at 838 Spadina Crescent East, in the Central Business District, of Saskatoon, Saskatchewan, Canada. The congregation was established as part of the Saskatoon Presbyterian Field Mission in 1885 after the North-West Rebellion. Meetings were held in homes, the Old Stone Schoolhouse, the Methodist Church and even the railway roundhouse until a wood church holding 160 was constructed near the river.