Lesmahagow Priory was a medieval Tironensian monastic community located in modern South Lanarkshire, Scotland. It was founded after John, Bishop of Glasgow and King David I of Scotland granted lands at Lesmahagow to Kelso Abbey with which to establish a new priory. It remained a dependency of Kelso Abbey. Control of the abbey was gradually secularized in the 16th century. Along with Kelso Abbey, it was turned into a secular lordship in 1607 for Robert Ker of Cesford, later earl of Roxburghe. Lesmahagow however passed into the hand of James Hamilton, 2nd Marquess of Hamilton in 1623.