Mapesu Private Game Reserve is a game reserve in Limpopo Province, South Africa. The reserve adjoins the Mapungubwe National Park and World Heritage Site, with which it shares a 12.5 km Northern border. The main entrance gate to the reserve is located approximately 7 km east of Mapungubwe's entrance gate. It was established in 2014 and covers an area of over 7,200 hectares. The reserve protects various bird, mammal and tree species and is slated to become part of the Greater Mapungubwe Transfrontier Conservation Area in phase 2 as part of the proposed Limpopo Valley Game Reserve.