"Me Wise Magic" is a song by Van Halen that appears on the rock band's 1996 compilation album Best Of – Volume I and became the band's 13th No. 1 Billboard Mainstream Rock Track, maintaining the No. 1 position for 6 weeks during the autumn of 1996. It was the first of two highly anticipated tracks recorded by the band with its original lead vocalist and songwriter, David Lee Roth.