Middlebourne Historic District is a national historic district located at Middlebourne, Tyler County, West Virginia. It encompasses 88 contributing buildings that include the civic, commercial, and residential core of Middlebourne. Most of the buildings in the district date from the late-19th and early-20th century in popular architectural styles, such as Queen Anne and Classical Revival. The two oldest are the Federal-style Quinif House (1805) and Gorrell-Wetzel House (1807). Other notable buildings include the Tyler County High School (1907), First National Bank (1902), Smith's Drug Store (c. 1890), Nadene Theater (c. 1920), The Powell-Shore House (c. 1898-99; the town's best example of Queen Anne Architecture), the Weekley House (c. 1905), the Huth-Fletcher House (1895), and United Meth