Middlemore is a suburb of the former Manukau City, one of the four cities that made up the conurbation of Auckland, in northern New Zealand, until 2010. The suburb is located on flat land at the southern end of the Otahuhu Isthmus, at the end of an arm of the Tamaki River. It is 18 kilometres southeast of Auckland city centre. It is located on State Highway 1 and the North Island Main Trunk Railway passes by the Middlemore Hospital.