New York State Route 105 (NY 105) is a 3.41-mile (5.49 km) state highway located within Nassau County, New York, in the United States. It begins in the town of Hempstead at an intersection with NY 106 in North Bellmore that also serves as that route's southern terminus. From here, it runs east through North Wantagh to an interchange with NY 135 before crossing into the town of Oyster Bay and ending at a junction with NY 107 in Massapequa. Jerusalem Avenue continues west past the route's western terminus as a county-maintained road to Hempstead and east as a town road to Massapequa State Park. NY 105 was assigned in the early 1930s.