State Route 253 (SR 253, OH 253) is a very short east–west state highway in the southern part of the U.S. state of Ohio. With an overall length of just 0.56 miles (0.90 km), the majority of SR 253 is a part of the Jesse Stuart Memorial Bridge, which crosses over the Ohio River near Franklin Furnace, Ohio. The western terminus of SR 253 is at about the midspan of the bridge, where it crosses the Kentucky State Line and becomes Kentucky Route 10 (KY 10). The eastern terminus of the highway is at a diamond interchange with U.S. Route 52 (US 52) near the eastern landing of the Ohio River crossing. The current SR 253 was established in the late 1980s. However, an earlier version of the highway existed in the Medina vicinity from the early 1920s until the late 1950s.