San Joseph de Escambe was an Apalachee mission community established in 1741 at the present-day community of Molino, Florida along the Escambia River north of Pensacola, lending its name both to the river and later to Escambia County, Florida. Taking its name from an earlier Apalachee mission community named San Cosme y San Damián de Escambe located far to the east in Leon County, Florida, this later Escambe mission was inhabited by refugee Apalachee Indians, including chief Juan Marcos Isfani (also rendered as Juan Marcos Fant), who had previously settled near the mouth of the river in 1718, having gathered a group of Apalachee refugees who had lived among the Creek Indians since the 1704 English-Creek raids that destroyed the Apalachee Province. After twenty years along the northern Span