Second Avenue is an avenue on the East Side of the New York City borough of Manhattan extending from Houston Street at its south end to the Harlem River Drive at 128th Street at its north end. A one-way street, vehicular traffic on Second Avenue runs southbound (downtown) only, except for a one-block segment of the avenue in Harlem. South of Houston Street, the roadway continues as Chrystie Street south to Canal Street. A bicycle lane in the left hand portion from 55th to 34th Street closes a gap in the Manhattan Waterfront Greenway. The bike lane extends from 125th Street all the way down to Houston Street. Second Avenue passes through a number of Manhattan neighborhoods including (from south to north) the Lower East Side, East Village, Gramercy Park, Murray Hill, Upper East Side, Yorkvil