John McCain ran for President of the United States in the 2000 presidential campaign, but failed to gain the Republican Party nomination, losing to George W. Bush in a campaign that included a bitter battle during the South Carolina primary. He resumed his role representing Arizona in the United States Senate in 2001, and Bush won the election. Bush was President of the United States from 2001 to 2009. McCain won re-election to the Senate in 2004 and 2010.