U.S. Route 40 enters Pennsylvania at West Alexander. It closely parallels I-70 from West Virginia until it reaches Washington where it follows Jefferson Avenue and Maiden Street. In Washington, US 40 passes to the south of Washington & Jefferson College. Following Maiden Street out of town, the road turns southeast toward the town of California. A short limited access highway in California and West Brownsville provides an approach to the Lane Bane Bridge across the Monongahela River. From here, the road continues southeast to Uniontown.