(This article is about the section of U.S. Route 80 in California. For the entire route, see U.S. Route 80.) U.S. Route 80 (US 80) was a U.S. highway in California that continued east across the country to Georgia. The western terminus was in San Diego, California, and US 80 continued east through the city on several different alignments through the years. The highway went through the Cuyamaca Mountains, encountering many switchbacks, before descending to El Centro. After passing through the sand dunes, the highway crossed the Colorado River into Yuma, Arizona.