The 1978 South Carolina United States House of Representatives elections were held on November 7, 1978 to select six Representatives for two-year terms from the state of South Carolina. The primary elections for the Democrats and the Republicans were held on June 13. All five incumbents who ran were re-elected, but the open seat in the 4th congressional district was taken by the Republicans from the Democrats. The composition of the state delegation after the elections was four Democrats and two Republicans.