The 1980 United States Senate election in Alaska was held on November 4, 1980. Incumbent Democratic United States Senator Mike Gravel ran for a third term in the United States Senate, but lost in the Democratic primary to Clark Gruening, a former state representative who was the grandson of Ernest Gruening, whom Gravel had defeated twelve years prior in an election for the same seat. Gruening later went on to lose the general election to Republican nominee Frank Murkowski, a banker.