The 1980 U.S. Senate election for the state of North Dakota was held November 4, 1980. The incumbent, Republican Senator Milton Young, was retiring. Republican Mark Andrews defeated North Dakota Democratic-NPL Party candidate Kent Johanneson to fill the vacated seat. Andrews, who had served as a Representative since 1965, easily received the Republican nomination, and the endorsed Democratic-NPL candidate was Kent Johanneson. Andrews and Johanneson won the primary elections for their respective parties.