Sir William Sambach (died 1653) was an English-born lawyer and politician of the seventeenth century who spent much of his career in Ireland, but was driven back to England by the political turmoil of the 1640s, and died there. His surname is probably a variant on Sandbach. Since that family preserved a collection of his papers it is likely that he was one of the Sandbachs of Tarporley, Cheshire, later famous as the owners of Hafodunos Hall.