Zanoterone
Zanoterone (INN, USAN) (former developmental codename WIN-49596), also known as (5α,17α)-1'-(methylsulfonyl)-1'-H-pregn-20-yno[3,2-c]pyrazol-17-ol, is a steroidal antiandrogen that was never marketed. It was investigated for the treatment of benign prostatic hyperplasia (BPH) but failed to demonstrate sufficient efficacy in phase II clinical trials, and also showed an unacceptable incidence rate and severity of side effects (e.g., breast pain and gynecomastia). As such, it was not further developed.
primaryTopic
Zanoterone
Zanoterone (INN, USAN) (former developmental codename WIN-49596), also known as (5α,17α)-1'-(methylsulfonyl)-1'-H-pregn-20-yno[3,2-c]pyrazol-17-ol, is a steroidal antiandrogen that was never marketed. It was investigated for the treatment of benign prostatic hyperplasia (BPH) but failed to demonstrate sufficient efficacy in phase II clinical trials, and also showed an unacceptable incidence rate and severity of side effects (e.g., breast pain and gynecomastia). As such, it was not further developed.
has abstract
Zanoterone (INN, USAN) (former ...... enzyme CYP3A4 in vivo in rats.
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CAS number
107000-34-0
DrugBank
FDA UNII code
XQ5V1W49JG
IUPAC name
(1R,3aS,3bR,5aS,10aS,10bS,12aS ...... 5,6]naphtho[1,2-f]indazol-1-ol
@en
PubChem
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Link from a Wikipage to an external page
Wikipage page ID
41,568,288
Wikipage revision ID
745,303,226
ChEMBL
ChemSpiderID
molecular weight
4.1657678e+2
routes of administration
smiles
CC12CCC3CCCC4C3C
synonyms
WIN-49596; -1'--1'-H-pregn-20-yno[3,2-c]pyrazol-17-ol
hypernym
comment
Zanoterone (INN, USAN) (former ...... it was not further developed.
@en
label
Zanoterone
@en
