(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate
(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP or HMB-PP) is an intermediate of the MEP pathway (non-mevalonate pathway) of isoprenoid biosynthesis. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) into HMB-PP. HMB-PP is then converted further to isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) by HMB-PP reductase (LytB, IspH). HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host.
(E)-4-hydroxy-3-methyl-but-2-enyl diphosphate(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate4-Hydroxy-3-methylbut-2-enyl diphosphate reductase4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseC5H12O8P21,2-dimethoxyethaanGamma delta T cellGcpEHMB-PPHmbpp1,2-dimethoxyethaanNon-mevalonate pathwayNon-peptidic antigenT cellTerpeneTerpenoid
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(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate
(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP or HMB-PP) is an intermediate of the MEP pathway (non-mevalonate pathway) of isoprenoid biosynthesis. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) into HMB-PP. HMB-PP is then converted further to isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) by HMB-PP reductase (LytB, IspH). HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host.
has abstract
(E)-4-Hydroxy-3-methyl-but-2-e ...... ng the B30.2 domain of BTN3A1.
@en
(E)-4-ヒドロキシ-3-メチル-2-ブテニル二リン酸（( ...... 、イソプレノイド生合成の非メバロン酸経路の中間生成物である。
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Le (E)-4-hydroxy-3-méthyl-but- ...... tipaludéens et les herbicides.
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alternative name
(E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate
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(E)-4-hydroxy-dimethylallyl pyrophosphate
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HDMAPP
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HMBDP
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IUPAC name
(E)-4-hydroxy-3-methylbut-2-enoxy-oxidophosphoryl phosphate
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page length (characters) of wiki page
Wikipage revision ID
1.013.806.092
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ImageFile
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ImageName
Ball-and-stick model, shown here as a 3- ion
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Chemical structure of HMB-PP
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477.199.926
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comment
(E)-4-Hydroxy-3-methyl-but-2-e ...... is absent from the human host.
@en
(E)-4-ヒドロキシ-3-メチル-2-ブテニル二リン酸（( ...... 、イソプレノイド生合成の非メバロン酸経路の中間生成物である。
@ja
Le (E)-4-hydroxy-3-méthyl-but- ...... tipaludéens et les herbicides.
@fr
label
(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate
@en
(E)-4-Hydroxy-3-méthyl-but-2-ényl-pyrophosphate
@fr
(E)-4-ヒドロキシ-3-メチル-2-ブテニル二リン酸
@ja
(E)-4-하이드록시-3-메틸뷰트-2-엔일 피로인산
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name
(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate
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