(R)-2-Methyl-CBS-oxazaborolidine
(R)-2-Methyl-CBS-oxazaborolidine is an organoboron catalyst that is used in organic synthesis. This catalyst, developed by Itsuno and Elias James Corey, is generated by heating (R)-(+)-2-(diphenylhydroxymethyl) pyrrolidine along with trimethylboroxine or methylboronic acid. It is an excellent tool for the synthesis of alcohols in high enantiomeric ratio. Generally, 2-10 mol% of this catalyst is used along with borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N,N-diethylaniline, or diborane as the borane source. Enantioselective reduction using chiral oxazaborolidine catalysts has been used in the synthesis of commercial drugs such as ezetimibe and aprepitant.
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(R)-2-Methyl-CBS-oxazaborolidine
(R)-2-Methyl-CBS-oxazaborolidine is an organoboron catalyst that is used in organic synthesis. This catalyst, developed by Itsuno and Elias James Corey, is generated by heating (R)-(+)-2-(diphenylhydroxymethyl) pyrrolidine along with trimethylboroxine or methylboronic acid. It is an excellent tool for the synthesis of alcohols in high enantiomeric ratio. Generally, 2-10 mol% of this catalyst is used along with borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N,N-diethylaniline, or diborane as the borane source. Enantioselective reduction using chiral oxazaborolidine catalysts has been used in the synthesis of commercial drugs such as ezetimibe and aprepitant.
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(R)-2-Methyl-CBS-oxazaborolidi ...... h as ezetimibe and aprepitant.
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alternative name
(R)-Methyl oxazaborolidine; (R)-(+)-2-methyl-CBS-oxazaborolidine
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IUPAC name
(3aR)-1-Methyl-3,3-diphenyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole
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34.272.227
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1.009.455.624
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OtherNames
-Methyl oxazaborolidine; --2-methyl-CBS-oxazaborolidine
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477.343.124
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(R)-2-Methyl-CBS-oxazaborolidi ...... h as ezetimibe and aprepitant.
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(R)-2-Methyl-CBS-oxazaborolidine
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(R)-2-Methyl-CBS-oxazaborolidine
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