(R,R)-Tetrahydrochrysene
(R,R)-Tetrahydrochrysene ((R,R)-THC) is a drug used to study the estrogen receptors (ERs) in scientific research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα. (R,R)-THC is a silent antagonist of ERβ, and, uniquely relative to other known ERβ antagonists, a of the receptor. (S,S)-Tetrahydrochrysene ((S,S)-THC) also binds to the ERs, but in contrast to (R,R)-THC, (S,S)-THC is an agonist of both ERα and ERβ and has 20-fold lower affinity for ERβ relative to (R,R)-THC.
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(R,R)-Tetrahydrochrysene
(R,R)-Tetrahydrochrysene ((R,R)-THC) is a drug used to study the estrogen receptors (ERs) in scientific research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα. (R,R)-THC is a silent antagonist of ERβ, and, uniquely relative to other known ERβ antagonists, a of the receptor. (S,S)-Tetrahydrochrysene ((S,S)-THC) also binds to the ERs, but in contrast to (R,R)-THC, (S,S)-THC is an agonist of both ERα and ERβ and has 20-fold lower affinity for ERβ relative to (R,R)-THC.
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(R,R)-Tetrahydrochrysene ((R,R ...... for ERβ relative to (R,R)-THC.
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CAS number
138090-06-9
PubChem
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48,938,400
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991,911,000
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drug name
-Tetrahydrochrysene
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IUPAC name
PubChem
SMILES
CCC1CC2=CC3=C1C4=CC=CO
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StdInChIKey
MASYAWHPJCQLSW-ZIAGYGMSSA-N
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(R,R)-Tetrahydrochrysene ((R,R ...... for ERβ relative to (R,R)-THC.
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(R,R)-Tetrahydrochrysene
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(R,R)-Tetrahydrochrysene
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