The 106th United States Colored Infantry Regiment was an infantry regiment of the United States Colored Troops, formed during the American Civil War. It was organized as the 4th Alabama Volunteer Infantry Regiment (African Descent) in late March 1864, and redesignated as the 106th United States Colored Infantry in May. The regiment spent its service on garrison duty at Pulaski, Tennessee, guarding railroads. It was consolidated into the 40th United States Colored Infantry Regiment in November 1865.