14-Methoxymetopon
14-Methoxymetopon is an experimental opioid drug developed by a team led by Professor Helmut Schmidhammer at the University of Insbruck in the mid 1990s. It is a derivative of metopon in which a methoxy group has been inserted at the 14-position. It is a highly potent analgesic drug that is around 500 times stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs. This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other eff
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14-Methoxymetopon
14-Methoxymetopon is an experimental opioid drug developed by a team led by Professor Helmut Schmidhammer at the University of Insbruck in the mid 1990s. It is a derivative of metopon in which a methoxy group has been inserted at the 14-position. It is a highly potent analgesic drug that is around 500 times stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs. This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other eff
has abstract
14-Methoxymetopon is an experi ...... ion with the κ-opioid receptor
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14-Methoxymetopon is een morfi ...... te dan vergelijkbare opioïden.
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CAS number
131575-03-6
ChEMBL
PubChem
Wikipage page ID
17,016,406
page length (characters) of wiki page
Wikipage revision ID
983,353,554
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chemical structure
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CAS number
ChEMBL
ChemSpiderID
IUPAC name
PubChem
SMILES
C[C@]12CCC[C@@]3OC
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StdInChIKey
DENICFHULARDRG-WEZQJLTASA-N
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synonyms
Verifiedfields
changed
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verifiedrevid
477,209,012
Watchedfields
changed
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wikiPageUsesTemplate
hypernym
comment
14-Methoxymetopon is an experi ...... ng effect is seen on other eff
@en
14-Methoxymetopon is een morfi ...... te dan vergelijkbare opioïden.
@nl
label
14-Methoxymetopon
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14-Methoxymetopon
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