Mabel Cahill won the singles tennis title by defeating challenger Elisabeth Moore, a 17-year old player from the Hohokus Valley Tennis Club, 5–7, 6–3, 6–4, 4–6, 6–2 in the Challenge Round of the 1892 U.S. Women's National Singles Championship. Moore had won the right to challenge Cahill by defeating 5–7, 6–1, 6–1 in the final of the All Comers' competition. The event was played on outdoor grass courts and held at the Philadelphia Cricket Club in Chestnut Hill, Philadelphia from June 21 through June 25, 1892.