The 1921 Arizona Wildcats football team represented the University of Arizona as an independent during the 1921 college football season. In their seventh season, under head coach Pop McKale, the Wildcats compiled a 7–2 record, shut out six of nine opponents, lost to the Centre Praying Colonels in the East-West Christmas Classic (the program's first bowl game appearance), and outscored all opponents, 418 to 68. The team captain was Walter William Wofford. Arizona's Harold "Nosey" McClellan led the nation in scoring with 124 points.