The 1st Missouri Infantry was an infantry regiment that served in the Confederate States Army during the American Civil War. Originally commanded by Colonel John S. Bowen, the regiment fought at the Battle of Shiloh, where it was engaged near the Peach Orchard on April 6, 1862. On April 7, during the Union counterattacks at Shiloh, the regiment was instrumental in preventing the Washington Artillery from being captured. The regiment was next engaged at the Second Battle of Corinth, where it outflanked several Union positions. On the second day at Corinth, the regiment was only minimally engaged. On November 7, the 1st Missouri Infantry was combined with the 4th Missouri Infantry to form the 1st and 4th Missouri Infantry (Consolidated), as a result of heavy battle losses in both regiments.