2019 Knoxville Challenger – Singles

Reilly Opelka was the defending champion but chose not to defend his title. Michael Mmoh won the title after defeating Christopher O'Connell 6–4, 6–4 in the final.

2019 Knoxville Challenger – Singles

Reilly Opelka was the defending champion but chose not to defend his title. Michael Mmoh won the title after defeating Christopher O'Connell 6–4, 6–4 in the final.