2021 ATP Lyon Open – Singles

Benoît Paire was the defending champion from when the event was last held in 2019, but chose to participate in Geneva instead. Stefanos Tsitsipas won the title, defeating Cameron Norrie in the final 6–3, 6–3.

2021 ATP Lyon Open – Singles

Benoît Paire was the defending champion from when the event was last held in 2019, but chose to participate in Geneva instead. Stefanos Tsitsipas won the title, defeating Cameron Norrie in the final 6–3, 6–3.