3-Hydroxymorphinan
3-Hydroxymorphinan (3-HM), or morphinan-3-ol, is a psychoactive drug of the morphinan family. It is the racemic counterpart to norlevorphanol. The dextrorotatory stereoisomer of the compound is an active metabolite of dextromethorphan, dextrorphan, and 3-methoxymorphinan, and similarly to them has potent neuroprotective and neurotrophic effects on LTS- and MPTP-treated dopaminergic neurons of the nigrostriatal pathway, but notably without producing any side effects (e.g., dissociation or hallucinations) or having any anticonvulsant actions. It does not seem to bind to the NMDA receptor, and instead, its neuroprotective properties appear result from inhibition of glutamate release via the suppression of presynaptic Ca2+ entry and protein kinase C activity. In any case, as such, the compou
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3-Hydroxymorphinan
3-Hydroxymorphinan (3-HM), or morphinan-3-ol, is a psychoactive drug of the morphinan family. It is the racemic counterpart to norlevorphanol. The dextrorotatory stereoisomer of the compound is an active metabolite of dextromethorphan, dextrorphan, and 3-methoxymorphinan, and similarly to them has potent neuroprotective and neurotrophic effects on LTS- and MPTP-treated dopaminergic neurons of the nigrostriatal pathway, but notably without producing any side effects (e.g., dissociation or hallucinations) or having any anticonvulsant actions. It does not seem to bind to the NMDA receptor, and instead, its neuroprotective properties appear result from inhibition of glutamate release via the suppression of presynaptic Ca2+ entry and protein kinase C activity. In any case, as such, the compou
has abstract
3-Hydroxymorphinan (3-HM), or ...... thylated analogue levorphanol.
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Bioavailability
CAS number
39131-41-4
Wikipage page ID
33,911,157
page length (characters) of wiki page
Wikipage revision ID
994,000,723
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alt
Ball-and-stick model
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Skeletal formula
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ATC prefix
None
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bioavailability
CAS number
ChemSpiderID
16,735,936
IUPAC name
-morphinan-3-ol
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SMILES
Oc3ccc4C[C@H]1NCC[C@@]2c4c3
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StdInChIKey
IYNWSQDZXMGGGI-NUEKZKHPSA-N
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Verifiedfields
changed
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verifiedrevid
477,344,702
wikiPageUsesTemplate
hypernym
comment
3-Hydroxymorphinan (3-HM), or ...... any case, as such, the compou
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label
3-Hydroxymorphinan
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