The 88th Illinois Infantry Regiment (nicknamed the Second Chicago Board of Trade Regiment) was an infantry regiment from Illinois that served in the Union Army during the American Civil War. The regiment mustered into service in September 1862 and was engaged at Perryville a month later. The unit subsequently fought at Stones River, in the Tullahoma campaign, at Chickamauga, at Missionary Ridge, in the Atlanta campaign, at Franklin, and at Nashville. The 88th Illinois especially distinguished itself at Stones River, Missionary Ridge, and Franklin. The regiment mustered out of service in June 1865.