ABT-737
ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of evolutionarily-conserved proteins that share Bcl-2 Homology (BH) domains. First developed as a potential cancer chemotherapy, it was subsequently identified as a senolytic (a drug that selectively induces cell death in senescent cells). Subsequently, it was reported that ABT-737 specifically induces apoptosis in senescent cells in vitro and in mouse models.
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ABT-737
ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of evolutionarily-conserved proteins that share Bcl-2 Homology (BH) domains. First developed as a potential cancer chemotherapy, it was subsequently identified as a senolytic (a drug that selectively induces cell death in senescent cells). Subsequently, it was reported that ABT-737 specifically induces apoptosis in senescent cells in vitro and in mouse models.
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ABT-737 is a small molecule dr ...... in vitro and in mouse models.
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IUPAC name
4-{4-[(4′-Chloro[1,1′-biphenyl ...... robenzene-1-sulfonyl)benzamide
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50,404,163
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1,022,684,857
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ABT-737 is a small molecule dr ...... in vitro and in mouse models.
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label
ABT-737
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