AM-1221
AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28 nM at CB2 and 52.3 nM at the CB1 receptor, giving it around 180 times selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However, despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a truly selective CB2 agonist, so the related compound AM-1241 is generally preferred for research purposes.
Wikipage redirect
primaryTopic
AM-1221
AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28 nM at CB2 and 52.3 nM at the CB1 receptor, giving it around 180 times selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However, despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a truly selective CB2 agonist, so the related compound AM-1241 is generally preferred for research purposes.
has abstract
AM-1221 is a drug that acts as ...... edule I Controlled Substances.
@en
CAS number
335160-53-7
FDA UNII code
SHC6SNM293
PubChem
Wikipage page ID
30,438,367
page length (characters) of wiki page
Wikipage revision ID
998,641,636
Link from a Wikipage to another Wikipage
CAS number
ChemSpiderID
26,286,945
IUPAC name
legal CA
Schedule II
@en
legal DE
NpSG
@en
legal UK
PSA
@en
legal US
Schedule I
@en
PubChem
11,604,318
SMILES
CN1CCCCC1CN2C=CCC4=CC=CC5=CC=CC=C54
@en
StdInChIKey
QGNIEJBBHMMNOZ-UHFFFAOYSA-N
@en
UNII
SHC6SNM293
@en
Verifiedfields
changed
@en
verifiedrevid
462,655,327
Watchedfields
changed
@en
wikiPageUsesTemplate
subject
hypernym
comment
AM-1221 is a drug that acts as ...... eferred for research purposes.
@en
label
AM-1221
@en