AM-938
AM-938 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxyprop-1-ynyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-938 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a triple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB2, with a Ki of 0.3nM at CB2 and 1.2nM at CB1, a selectivity of around 4x.
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AM-938
AM-938 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxyprop-1-ynyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-938 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a triple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB2, with a Ki of 0.3nM at CB2 and 1.2nM at CB1, a selectivity of around 4x.
has abstract
AM-938 (part of the AM cannabi ...... 1, a selectivity of around 4x.
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CAS number
303113-08-8
FDA UNII code
NPU5SWP5ZS
PubChem
Wikipage page ID
17,361,788
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Wikipage revision ID
1,022,957,153
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CAS number
ChemSpiderID
IUPAC name
PubChem
10,646,208
SMILES
Oc2ccCCCCCCC
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StdInChIKey
FFRHKSZKZQWCOY-UOTIDGTBSA-N
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UNII
NPU5SWP5ZS
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Verifiedfields
changed
@en
verifiedrevid
448,104,384
Watchedfields
changed
@en
wikiPageUsesTemplate
hypernym
comment
AM-938 (part of the AM cannabi ...... 1, a selectivity of around 4x.
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label
AM-938
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