Advanced Simulation Library (ASL) is free and open-source hardware-accelerated multiphysics simulation platform. It enables users to write customized numerical solvers in C++ and deploy them on a variety of massively parallel architectures, ranging from inexpensive FPGAs, DSPs and GPUs up to heterogeneous clusters and supercomputers. Its internal computational engine is written in OpenCL and utilizes matrix-free solution techniques. ASL implements variety of modern numerical methods, i.a. level-set method, lattice Boltzmann, immersed Boundary. Mesh-free, immersed boundary approach allows users to move from CAD directly to simulation, reducing pre-processing efforts and number of potential errors. ASL can be used to model various coupled physical and chemical phenomena, especially in the fi