Agave caymanensis is a species of agave that is endemic to Grand Cayman, Little Cayman and Cayman Brac in the Cayman Islands. It can be found in dry shrubland at all elevations of the islands. A. caymanensis gradually forms a short trunk, that is clothed in dead leaves. It can reach heights of 4 m and widths of 3 m with a rosette of massive, succulent leaves rimmed with thorns. It is monocarpic, and flowering is quite synchronous. Young rock iguanas sometimes use the hollow core of dead flower spikes as a refuge. This species was previously confused with until described by Proctor as a separate species in 2012.