The Agawam River is a 10.7-mile-long (17.2 km) stream in southeastern Massachusetts, USA, that is part of the estuary watershed. The Agawam River is named in honor of the peaceful Native Americans that helped the Massachusetts Bay Colony establish its first Connecticut River Valley settlement at Springfield, Massachusetts in 1636, and helped it to flourish while many of the Connecticut Colony settlements south of Springfield were attacked or destroyed by more war-like Native American tribes.