Alpe d'HuZes is a Dutch fundraising event for combating cancer in which people climb, typically by bike, six times in a single day. The mountain Alpe d'Huez is well-known in the Netherlands as one of the main Tour de France mountains where Dutch cyclists have been traditionally relatively successful. The event is organized by Stichting Alpe d'HuZes, whose name is a combination of the name of the mountain Alpe d'Huez and the Dutch word "zes" (six) and its motto is "opgeven is geen optie" (quitting is not an option).