Anger's Block is a historic commercial building in Winona, Minnesota, United States. Built in 1872, it is one of the oldest surviving commercial buildings in Winona's central business district. The building was listed on the National Register of Historic Places in 1978 for its local significance in the theme of architecture. It was nominated for its early status among Winona's downtown buildings, which is furthered by the survival of its original architectural plans. In 1998 the building was also listed as a contributing property to the Winona Commercial Historic District.