Annie Sinclair Cunningham (October 29, 1832 – February 17, 1897) was a Scottish-born American religious worker. Mrs. Cunningham was one of the founders of the Woman's Foreign Missionary Society of the Presbyterian Church. She was president of the Washington Presbytery Mission Society for a number of years, one of the secretaries of the Chautauqua Missionary institute, and served as a leader in local works of charity. While in Scotland, she was chosen president of the Missionary Association of the World.