BC-LI-0186
BC-LI-0186 is a compound that acts as an inhibitor of the GTPase enzyme leucyl-tRNA synthetase (LRS). This enzyme acts as part of the mTOR complex and acts as a leucine sensor which stimulates mTORC1 in the presence of leucine. BC-LI-0186 blocks the docking site for mTORC1 and thereby prevents the mTOR activation and increased protein synthesis which is usually triggered by branched-chain amino acids such as leucine, yet without inhibiting the separate catalytic activity of LRS. This may have potential applications in the treatment of cancer, and BC-LI-0186 has also been shown to promote muscle regeneration after injury.
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BC-LI-0186
BC-LI-0186 is a compound that acts as an inhibitor of the GTPase enzyme leucyl-tRNA synthetase (LRS). This enzyme acts as part of the mTOR complex and acts as a leucine sensor which stimulates mTORC1 in the presence of leucine. BC-LI-0186 blocks the docking site for mTORC1 and thereby prevents the mTOR activation and increased protein synthesis which is usually triggered by branched-chain amino acids such as leucine, yet without inhibiting the separate catalytic activity of LRS. This may have potential applications in the treatment of cancer, and BC-LI-0186 has also been shown to promote muscle regeneration after injury.
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BC-LI-0186 is a compound that ...... cle regeneration after injury.
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CAS number
695207-56-8
PubChem
Wikipage page ID
66,169,770
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1,002,267,659
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ChemSpiderID
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PubChem
SMILES
CC1=CCC
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StdInChIKey
SQYWMHPZMHDCHP-UHFFFAOYSA-N
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BC-LI-0186 is a compound that ...... cle regeneration after injury.
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label
BC-LI-0186
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