Belumosudil
Belumosudil (formerly KD025 and SLx-2119) is an experimental drug being explored for the treatment of chronic graft versus host disease (cGvHD), idiopathic pulmonary fibrosis (IPF), and moderate to severe psoriasis. It is an inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II). Belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signaling pathways which play major roles in pro- and anti-inflammatory immune cell responses. A genomic study in human primary cells demonstrated that the drug also has effects on oxidative phosphorylation, WNT signaling, angiogenesis, and KRAS signaling. Originally developed by Surface Logix, Inc, Belumosudil was later acquired by Kadmon Corporation. As of July 2020 the drug was in completed o
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Belumosudil
Belumosudil (formerly KD025 and SLx-2119) is an experimental drug being explored for the treatment of chronic graft versus host disease (cGvHD), idiopathic pulmonary fibrosis (IPF), and moderate to severe psoriasis. It is an inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II). Belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signaling pathways which play major roles in pro- and anti-inflammatory immune cell responses. A genomic study in human primary cells demonstrated that the drug also has effects on oxidative phosphorylation, WNT signaling, angiogenesis, and KRAS signaling. Originally developed by Surface Logix, Inc, Belumosudil was later acquired by Kadmon Corporation. As of July 2020 the drug was in completed o
has abstract
Belumosudil (formerly KD025 an ...... icine. Retrieved 25 July 2020.
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CAS number
911417-87-3
FDA UNII code
834YJF89WO
PubChem
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Wikipage page ID
57,976,285
page length (characters) of wiki page
Wikipage revision ID
994,881,922
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CAS number
IUPAC name
PubChem
11,950,170
routes of administration
Oral administration
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SMILES
CCNCCOC1=CC=CCC2=NC3=CC=CC=C3CNC4=CC5=CNN=C5
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StdInChI
InChI=1S/C26H24N6O2/c1-1628-24 ...... 27-32-22/h3-14,16H,15H2,1-2H3,
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StdInChIKey
GKHIVNAUVKXIIY-UHFFFAOYSA-N
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wikiPageUsesTemplate
comment
Belumosudil (formerly KD025 an ...... 20 the drug was in completed o
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label
Belumosudil
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