Berzosertib
Berzosertib (VE-822, VX-970, M6620) is a drug originally invented by Vertex Pharmaceuticals and licensed to Merck KGaA, Darmstadt, Germany for development. It acts as a potent inhibitor of the enzyme ataxia telangiectasia and Rad3 related (ATR) and with lower potency as an inhibitor of ATM serine/threonine kinase (ATM). These enzymes are both involved in detecting DNA damage as part of cell cycle checkpoints during cell division. By inhibiting their activity, berzosertib interferes with the ability of rapidly dividing cells to detect damage to DNA, and this makes it useful as a potential treatment for some forms of cancer by causing accumulation of DNA damage in the cancer cells and thus reducing their viability. It has progressed furthest in trials for the treatment of ovarian cancer, tho
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Berzosertib
Berzosertib (VE-822, VX-970, M6620) is a drug originally invented by Vertex Pharmaceuticals and licensed to Merck KGaA, Darmstadt, Germany for development. It acts as a potent inhibitor of the enzyme ataxia telangiectasia and Rad3 related (ATR) and with lower potency as an inhibitor of ATM serine/threonine kinase (ATM). These enzymes are both involved in detecting DNA damage as part of cell cycle checkpoints during cell division. By inhibiting their activity, berzosertib interferes with the ability of rapidly dividing cells to detect damage to DNA, and this makes it useful as a potential treatment for some forms of cancer by causing accumulation of DNA damage in the cancer cells and thus reducing their viability. It has progressed furthest in trials for the treatment of ovarian cancer, tho
has abstract
Berzosertib (VE-822, VX-970, M ...... promise in treating COVID-19.
@en
CAS number
1232416-25-9
ChEBI
DrugBank
FDA UNII code
L423PRV3V3
KEGG
PubChem
Wikipage page ID
64,365,868
page length (characters) of wiki page
Wikipage revision ID
1,020,856,908
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ATC prefix
None
@en
CAS number
ChEBI
ChemSpiderID
30,773,968
DrugBank
DB11794
@en
IUPAC name
KEGG
D11148
@en
PubChem
59,472,121
SMILES
CCSC1=CC=CC2=CN=CN
@en
StdInChIKey
JZCWLJDSIRUGIN-UHFFFAOYSA-N
@en
UNII
L423PRV3V3
@en
wikiPageUsesTemplate
subject
comment
Berzosertib (VE-822, VX-970, M ...... eatment of ovarian cancer, tho
@en
label
Berzosertib
@en