William Enlow Amos (July 6, 1898 – April 26, 1987) was an American college football player and coach. He is considered to be one of the best college football players in Washington & Jefferson College history. Amos was born in Graysville, Pennsylvania. He attended The Kiski School and was a veteran of World War I. As a fullback for Washington & Jefferson for was named to the 1926 College Football All-America Team and the 1927 College Football All-America Team. In 1932, Amos was seriously injured in an automobile collision, sustaining a fractured skull and broken left arm.