Binding immunoglobulin protein
Binding immunoglobulin protein (BiP) also known as (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) or (Byun1) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery and plays a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BiP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER.
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AB5 toxinAdenylylationAntigen processingBIPBiP proteinBinding proteinBip internal ribosome entry site (IRES)Chaperone (protein)DNAJC3DNA damage-inducible transcript 3Endomembrane systemEndoplasmic reticulumFic/DOC protein familyGRP78Glucose-regulated proteinGlucose regulate protein 78Grp78HSPA5HSPA5 (gene)Heat shock 70kDa protein 5Heat shock proteinHousekeeping geneHsp70IGFBP3Immunoglobulin-binding proteinIntegrated stress responseLipid-binding serum glycoproteinList of human protein-coding genes 2OSU-03012Omega-3 fatty acidPPIBRicinSIL1ThyroglobulinTransloconUSP27XUnfolded protein responseXBP1
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Binding immunoglobulin protein
Binding immunoglobulin protein (BiP) also known as (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) or (Byun1) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery and plays a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BiP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER.
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Binding immunoglobulin protein ...... folded polypeptides in the ER.
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Binding immunoglobulin protein ...... folded polypeptides in the ER.
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Binding immunoglobulin protein
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